… Though there were no changes in pharmacokinetic outcomes of … of oxycodone’s metabolites
to the overall clinical effects and impact on inter-individual variations in clinical effects. …

… of great significance to study whether there is an interaction between anlotinib and oxycodone.
… a single administration of anlotinib, there was no significant change in the metabolism of …

… effects associated with the administration of oxycodone in … This relatively small structural
change appears to impact the … to participate in Cytochrome P450-mediated metabolism in the …

… the inhibitory effects of these two inhibitors on oxycodone, we examined their inhibitory …
inhibited the metabolism of oxycodone in RLMs and HLMs, leading to the changes in its …

… analgesic drug improving their analgesic effects. This narrative … after oxycodone administration
and thus its clinical relevance is … Also, we have an opportunity to change the guidance of …

… we see in the clinical effects of various exogenous opioids. … for the MOR) that may change
its functional properties and … primary metabolizer of both oxycodone and fentanyl. CYP2D6 …

… the metabolism of oxycodone, a potent prescription opioid. The clinical consequences of this
… a maximum of 60 days from oxycodone initiation, regardless of changes in therapy. Patients …

The misuse of drugs and alcohol poses obvious health risks to afflicted individuals. When
addressing these health risks, the overarching concerns generally relate to the direct effects …

… discovered to have similar clinical significance in terms of polymorphisms, … Cytochrome
P450-mediated changes in oxycodone pharmacokinetics/ pharmacodynamics and their clinical …

… impact in longitudinal designs. Future studies should also seek to develop cost effective
CYP2D6 screening methods to help support the clinical significance … the clinical significance of …